In this paper, a collaboration of topology control for full-reach ability networks and a genetic algorithm with dynamic mutation to discover the escape path in a blaze scene is proposed. The proposed scheme for transmission range efficiently solves the isolated nodes problem. The proposed algorithm powerfully improves the performance of traditional genetic algorithm to avoid the possible solutions falling in local optimal. There are various experimental simulations to verify the effectiveness, reliability and timeliness of performance of proposed approaches. In the developed wireless sensor network, each sensor in a network can connect at least two sensors and deliver each other through the obtained transmission range to form a full reach ability network. Hence, an excellent blaze escape system with full reach ability network topology and real-time routing method has been developed through the proposed approaches in this paper. This system will benefit the security and safety of people in a blaze scene.