As the link and bridge of the whole electrical system, airplane wiring harness provides power and communication support to the electronic equipment and has an important impact on airplane performance and safety. Airplane wiring harness is not only the last step in the electrical design, but also in the early part of the assembly, so all the complexity of the connection determines its manual mode of production. With a large number of applications of modern military airplane of electronic equipment, substantial increase in airplane wiring harness complex as well as more frequent engineering changes propose new requirements on agile development and reliable quality on the airplane wiring harness. In response to the long production cycle, high error rate and low level of automation on airplane wiring harness, the paper researches on the optimization of airplane harness process wiring route based on new Military Airplane and provides a method and technical support to harness research and development units with the implement of concurrent engineering.