Transparent oxyfluoride nano-glass-ceramics with highly efficient up-conversion and adjustable color luminescence were developed in the 50SiO2-15AlF3-10BaF2-15PbF2-(9.3-x)GdF3 -0.5YbF3-0.2TmF3-xHoF3 (x = 0.02, 0.05, 0.10, 0.50)composition in mol%. X-ray diffraction measurements revealed that heat treatments of the oxyfluoride glasses cause the precipitation of rare-earth ions co-doped fluorite-type of β-PbF2 in the glass matrix. Under 980 nm laser excitation, intense red, green and blue up-conversion luminescences were simultaneously observed in these transparent nanoglass-ceramics owing to the successive energy transfer from Yb3+ to Ho3+ and Tm3+ ions. Various colors of luminescence, including bright perfect white light, can be tuned by adjusting the concentrations of the Ho3+ ions in the material. A possible energy transfer process and up-conversion luminescence mechanism in the nano-glass-ceramics are proposed and discussed.