We consider sparsity-driven change detection (CD) for human motion indication in through-the-wall radar imaging and urban sensing applications. Stationary targets and clutter are removed via CD, which converts a populated scene into a sparse scene of a few human targets moving inside enclosed structures and behind walls. We establish appropriate CD models for various possible human motions, ranging from translational motions to sudden short movements of the limbs, head, and/or torso. These models permit scene reconstruction within the compressive sensing framework. Results based on laboratory experiments show that a sizable reduction in the data volume is achieved using the proposed approach without a degradation in system performance.