The natural degree of electronic schoolbag interface interaction is decided to the key of electronic schoolbag's usability, applicability and usability. This paper discusses the development of electronic schoolbag and its evolution of interface interaction, according to the natural ergonomics theory of electronic schoolbag interface interaction, this paper expounds the natural the feature of the electronic schoolbag interface interaction and the naturalization's future development trendcy of electronic schoolbag interface interaction based on ergonomics.