This paper proposes a novel Maximum Power Point ] Tracking (MPPT) control method of thermoelectric power generation. This paper reveals the characteristics and the internal resistance of thermoelectric power module (TM). Analyzing the thermoelectric power generation system with boost chopper by state space averaging method, the output voltage and current of TM are estimated by with only single current sensor. The proposed method can seek without calculating the output power of TM in this proposed method. The basic principle of the proposed MPPT control method is discussed, and then confirmed by digital computer simulation using PSIM. Simulation results demonstrate that the output voltage can track the maximum power point voltage by the proposed MPPT control method. The generated power of the TM is about 0.13W when the j temperature difference is 40 °C. This is well accorded with the, V-P characteristics of the thermoelectric power module.