In this paper, we present an association rule-based bilateral multi-issue negotiation model which uses association rules to describe the interdependence of issues. Moreover, we propose a novel time-dependent negotiation strategy which based on association rules. In the negotiation process, agent can adjust the associated issues' value intervals and negotiation time dynamically according to the corresponding association rules, thus reducing the number of interactions appropriately to improve the flexibility and efficiency of negotiation process. The experimental results show that the model can improve the overall utility and efficiency.