In this paper, we discuss the problem of inter-cell interference cancellation for uplink coordinated multipoint system based on non-binary transmission. Firstly, the design of coder, mapper, demapper and decoder for non-binary code modulation system has been analyzed. Then, the cooperative detection for multi-cell non-binary uplink is presented. The performance comparison based on simulation results indicates that, with cooperative detection, the non-binary system can outperform the one without cooperative processing.