A solution for the delivery problem (vehicle routing, scheduling, and dispatching problem with single depot) is proposed to bridge the gap between conventional methods and complex situations in the real world. The HIMS model (a computational model with Hierarchical Multiplex Structure) is also applied for solving the delivery problem. The HIMS model contains 3 layers: Atomic layer (system cost can be controlled by a heuristic method), Molecular layer (system state can be adjusted by a heuristic method and an optimal calculation), and Individual layer (a system balance can be modified based on information technology service). Experiments with two cases (full or minimum working vehicles) are performed. The experimental results and the evaluations by experts show that the solution provides a feasible and efficient tool to solve the delivery problem in the real world.