In this paper, a new type of differential far end crosstalk cancellation mechanism for high speed differential link is introduced. By optimizing the PCB routing, or enforcing a specific differential pin-out pattern, the crosstalk contribution from a different component or section of the link can cancel each other and result in a significant crosstalk reduction at the receiver. On the other hand, this paper also addresses another aspect of the crosstalk cancellation scheme: the crosstalk contribution from different link components may be un-intentionally cancelled out in full link simulation, and results in favorable but wrong simulation results. Suggestions on how to avoid this type of problem is given in the paper.