The remediation of typical acidified soil collected from Longli ecological park in Guizhou province has been carried out. The research was studied by simulated acid rain leaching of soil columns equipment indoor. At the same time, we also configured simulated acid rain solution whose pH value was 3.50. The remediation effects of five kinds of remediation agents which were limestone, magnesite, dolomite, blast furnace slag and coal ash were investigated. The result indicates that the remediation effects of limestone, magnesite and dolomite on typical soil are much better than that of blast furnace slag and coal ash, and the effect of dolomite is the best with the dosage of 300g/m2. In addition, the remediation effects of the soil in different depth decrease in the order of 0∼20cm>20∼40cm>40∼60cm.