In order to study the effect of the traditional Chinese medicine “Huchuanqing Decoction” in preventing and curing the chicken infectious bronchitis disease, a chicken infectious bronchitis model was established by artificial infecting chicken infectious bronchitis virus. This paper studied the effect of virus on the chicken production performance, the changes of cytokine IFN-γ, IL-6 and TNF-α concentration in chicken serums and the effect of Huchuanqing Oral Liquid on it. The results provided evaluation indexes and the basis in developing Chinese medicines for preventing and curing the chicken infectious bronchitis.