Through 3 experiments, the high-effective technology for wheat production in dry-land had been studied. The first experiment was about the condition of soil nutrient and water content in irrigated and dry-land wheat of high yield; the second experiment was about the changes of dry weight of root system after anthesis and yield in different soil thickness in dry land wheat by using soil column, and the third experiment was about the effects of fertilizer application depth on nitrogen utilization and yield of wheat in dry land by using micro-plot, and all the experiments were finished in open field. The results showed: The dry-land soil was fertile and it would be increased the water-retention capacity and water using efficiency and got high yield for wheat production comparing with the irrigated field. The thicker the soil was, the more beneficial the result was to the root system growth of wheat and the lower the ratio of root system distributing in upper levels was. While the thinner the soil was, the higher the ratio of grain yield coming from the store organ transported before anthesis was, and the lower the grain yield was. There was no significant difference between T3 and T4 (CK),and T4 was apparently different from T1 and T2. Meanwhile, with fertilizer applying in subsurface layer of 20–40cm, more nitrogen was absorbed, the utilization ratio and recovery ratio of fertilizer nitrogen increased, the remainder ratio in soil and loss ratio of fertilizer nitrogen decreased, and yield of wheat improved. However, when the fertilizer applied in surface layer of 0–20cm and deep layer of 60–80cm, the results were contrary. It was concluded that the minimum soil depth was 160 cm and the depth of 20–40cm fertilizer application was the best for gaining higher yield and nitrogen fertilizer utilization efficiency in dry land wheat, and the results can be the basis for taking administration program to obtain high yield and high efficiency in dryland wheat.