This paper presents a case study of a 10-story concrete frame structure designed according to the Chinese Code GB50010-2002. To reduce the potential of progressive collapse due to single column failure, progressive collapse analysis is carried out following the DoD2009 guidelines. It is observed that most of longitudinal beams in superstructure and floors above the failure column would collapse as the results of removing an exterior column, no beams and floors would collapse when an interior column at ground floor was removed, and only the beams in short span would collapse when an interior column at upper floor was removed. Adequate reinforcements in the beams of superstructure and adequate ties among floors, beams and columns can be used to avoid the progressive failure of structure, after failure of particular column.