This paper indicates many existing problems in majors setup. These problems include: excessive development of some majors; incomplete related management system; lack of majors' transformation and none of the exit mechanism; curriculum system, teaching team development and other issues. To solve these problems and improve the development of the university majors, authors analyze some factors that can influence the issues. Finally, it provides some suggestions to strengthen majors' management, and makes it to meet the demands of the social and economic development.