Worldwide cardiovascular diseases are the major cause of death. Beside heart transplants, which is a limited option due to the available number of human donor hearts, artificial hearts are the only therapy available for terminal heart diseases. For various reasons a total implantable artificial heart is desirable. But the limited space in the human thorax sets rigorous restrictions regarding the weight and the dimensions of the device. Nevertheless the appropriate functionality of the artificial heart must be ensured and blood damage must be prevented. These requirements set further restrictions to the drive of this device. In this paper two optimization methods, which are manual parameter variation and Differential Evolution (DE) algorithm, are presented, to match the specifications of an artificial heart.