On the basis of spatial aggregation, the up scaling technique was one of methods for the regional application of crop growth model. In this paper, the aggregation technique of regional soils, varieties and cultivar measures was discussed for regional application of rice growth model in county level, and the difference of rice development and yield among the county stations of Suzhou and Lianyungang, Jiangsu, was explored with experiment data from national agrometeological stations at Kunshan and Ganyu, Jiangsu and RCSODS. The results showed although the development stages were similar among counties, the yield difference was significant, After aggregation of model inputs, the RMSEs between statistical and simulated yields were 742kg/ha and 975kg/ha for Suzhou and Lianyungang respectively, and the NRMSEs were 8.7% and 12.4%, which indicated the spatial aggregation approach for model inputs was suited to regional application of rice growth model.