In this paper, we have proposed the signal separation and equalization schemes for MFSK signals using FDE (Frequency Domain equalization) with CP (Cyclic Prefix) and the MLD (Maximum Likelihood Detection) with ZP (Zero Padding) on quasi-static MIMO frequency selective channels. Through computer simulations, we have verified that the MLD with ZP exhibits the better BER characteristics than the conventional FDE with CP. Moreover, we have decreased the computational complexity of MLD using M algorithm.