In Speculative Multithreading, data dependence that limits the speedup of speculative parallelization needs to be resolved to achieve a high performance. This paper designs a synchronization execution model, with the support of compiler, to synchronize store and load instructions that frequently have data dependence on each other. We use hardware profiler to gather dependence violation information of memory data, and the profiler information is fed back to the compiler. The compiler analyzes the synchronization efficiency, select store/load pairs of great synchronization potential, and inserts synchronization instructions using insertion algorithm. Loop threads and non-loop threads can both be synchronized. The hardware support is also given in the paper. The experimental results show that the synchronization under the compiler support can effectively resolve some memory data dependence and improve the performance of the speculative execution.