In this present paper, we showed that wavelet analysis (WA) has the potential for extracting specific features from measured arterial diameter and pressure waveforms. The fifth detail of the Daubechies 4 (Db4) wavelet appears to be the most appropriate level for application, in order to analyze artery waveforms and was used to characterized arterial de-endothelization (DE). Raises in smooth muscle tone induced by (DE) tended to increase arterial stiffness and therefore that WA details embed the information of the diameter and pressure pulse that contains the signature of effects of wave travel and reflection affected by arterial stiffness.