This paper presents a design method of multi-user precoding design concatenation, Multi-user interference suppression and multi-user MIMO (Multiple Input Multiple Output) system performance (such as bit error rate, etc.) optimization can be conducted separately. Furthermore, Proposed a selection criteria and methods based on game theory, The utilization of multi-user precoding concatenation can be obtained a better multi-user multi-cell interference suppression effect. In addition, Proposed a new method of power adjustment based on power load, All users can be obtained better power distribution under the different SNR (Signal to Noise Ratio).