More admission of students into colleges challenges the teaching of English majors to a great extent. This article illustrates the practice of ESA model in teaching English major's large class comprehensive reading and further proves that this model is an effective and practical approach in language teaching. Based on this teaching experiment, it is shown that ESA model in English comprehensive reading with the combination and flexible use of Engage-Study-Activate enables students to be the center of class, activates their interest and realizes the role exchange in teaching and learning to enhance students' overall ability in using language.