After investigating the current teaching of database application technology, the present paper proposes a new curriculum design based on innovative engineering education. Assisted by modern information technology, this student-centered, application-oriented curriculum design stresses personalized and open teaching modes. It integrates out-of-class practices, lectures, activities into in-class theoretical introduction, and tries to balance class instruction and extracurricular application activities and improve overall abilities of the students. The satisfying teaching effect proves that this reformed teaching mode can effectively foster and improve students' synthetic abilities, especially their innovative abilities in their progressive learning and practicing designed by their common and diversified requirements and characters. So it is effective in improving the employability of the graduates of Computer Science and Technology.