China's rapid growth of energy consumption can be attributed to many factors, among which Low energy efficiency is dominant. Energy efficiency is determined by the level of production technology, so technological innovation should be the effective way to improve energy efficiency. In economic society, enterprises are the core players of technological innovation. In China, the large and medium-sized industrial enterprises (LMIEs) form the backbone of industrial sector, so the technological innovation of LMIEs is the decisive influence on energy efficiency. In this paper, we firstly use factor analysis method to do evaluation on the technological innovation capacity of LMIEs in 30 regions of China according to the data of 2007, and then apply regression analysis to research the relationship between the regional technological innovation capacity of LMIEs and regional energy consumption intensity. The study results show there is significant negative correlation between them, which suggests the energy efficiency can be boosted by promoting technological innovation capacities of LMIEs.