How to solve the problems of monitoring dynamic and variable quality variation, diagnosing the abnormal variation and adjusting the process quality at the right moment, is a difficult problem that modern manufacturing enterprise faces challenges of process quality control. An intelligent decision support system for process quality control is presented, the corresponding decision support modules (such as data acquisition, data management, process analysis, dynamic diagnosis, real-time adjustment, expert system and so on) are built based on the design idea of decision support system with multi-structure through the share of resource and information; and the functions of each module are designed and described, and the solutions of decision are proposed. So, the work of this paper provides a theoretical basis and technological insurance for the development of the intelligent decision support system for process quality control.