This research combines Radio Frequency Identification (RFID) with multi-agent technology, it apply to children's safety of care in kindergarten. It use RFID to position, first, child-care worker will help children put on Tag, and reader receive signal to get RSSI, and through the system to get the children's location. The Tag's data not only include signal, quality of signal, time of reach reader, but also have children's temperature. The message makes care staff to know children's physical condition. Our system composed by multi-agent. After agent communicate to decide to send warning or not. If the message is wrong, system can through user's feedback to self-regulated learning. It not only increase processing efficiency of unexpected event and system, but also decreases probability of human negligence. Besides, the agent's features use autonomy and logic makes system can continuous monitoring and automated analysis to determine the current status. So system can improve the contingency measures, and make care staff can handle unexpected condition immediately and provide a perfect kindergarten.