The classical linear control method based on small-perturbation theory couldn't adapt to the complex flight environment and large airspace, strong coupling and nonlinear characteristics of re-entry vehicle. A new robust control method combining fuzzy sliding mode control and nonlinear dynamic inversion is presented. Dynamic inversion controller can approximately decouple the nonlinear plant into three separate one-order linear systems. To eliminate tracking errors caused by dynamic inversion and disturbances, the fuzzy sliding mode controller outputs the input signal needed by dynamic inversion controller. Nonlinear simulation of a control system using MATLAB/SIMULINK shows that the designed controller can provide the excellent tracking performance and robustness of control system.