Objective To evaluate the influence of monochrome LCDs with different resolutions on the detection performance of pulmonary nodules. Materials and Methods 93 chest images were selected, including 55 normal images and 38 positive images. Three high-, three mid-, and three low-experienced radiologists interpreted these images using three types of displays. Regarding the presence of nodule, five-point confidence level rating scale was used: definite absence, probable absence, indetermination, probable presence and definite presence. Observer marked their confidence level of every image according to the presence of pulmonary nodule on the given display. Software SPSS 13.0 was used for statistical analysis. Results The areas under ROC curves for high-experienced radiologists were 0.774, 0.784 and 0.816 on 2MP, 3MP and 5MP display, respectively; those for mid-experienced radiologists were 0.754, 0.764 and 0.768, respectively; and those for low-experienced radiologists were 0.695, 0.754 and 0.774, respectively. There were no substantial differences among different types of displays or radiologists of different aptitudes. Conclusion It' s equivalent of the detection performance of pulmonary nodules among on 2MP, 3MP and 5MP monochrome LCDs when there is no restriction on the use of image post-processing tools.