In this paper, Canonical Correspondence Analysis (CCA) method of quantitative ecology was employed to analyze the relationship between landscape change and its driver factors in Jinghe River Watershed. which located in middle of the Loess Plateau. The watershed was divided into 15 sub-watersheds by hydrological tools. Fourteen landscape indices and nine driver factors in each sub-watershed were measured carefully using GIS statistics and field surveying. The result showed that Land cover appears regional difference in the Jinghe River Watershed and its main drive factors are slope, rainfall, population density, farm mechanism and river density. Slope is positive to forest land and shrub land distribution, while negative to that of building land. Annual precipitation is positive to forest land distribution. Population density is positive to farm land and that of building land distribution. Farm mechanism is negative to farm land ratio and that of shrub land ratio.