In order to strengthen management of road hazardous materials transportation, safeguard public interest and social safety, the influence factors that affect the safety supervision level of hazardous materials transportation are systematically and comprehensively analyzed, then the evaluation index system is formed and the index weight is determined with the analytical hierarchy process method. Furthermore, it uses the fuzzy comprehensive evaluation to evaluate the supervision present of road hazardous materials transportation. The evaluation result indicated that the safety supervision level of road hazardous materials transportation in Jilin province is general. To improve the safety supervision level of road hazardous materials transportation, the influence factor weight is calculated and the main influence factor is identified, therefore, the countermeasure and proposal of improving the management level of road hazardous materials transportation in Jilin province are provided for the relevant departments.