Applying new sensing technology to healthcare maybe part of a solution to the financial and demographic crisis facing global healthcare systems. Researchers applying new approaches to noninvasive patient monitoring and diagnostics are assisted by the features of Sensing Health with Intelligence, Modularity, Mobility and Experimental Reusability (SHIMMER™), a flexible sensing platform. Integrated peripherals, open software, modular expansion, specific power management hardware, and a library of applications supported with platform validation provide SHIMMER with advantages over many other medical research platforms.