Operations research is an applied science, and is widely used in current scientific knowledge and mathematical methods to solve practical problems in modern management and provided the best quantitative basis for decision-makers. Optimization toolbox extends the capability of the Matlab numeric computing environment. The toolbox includes routines for many types of optimization. This article solves the problem of Operational Research in modern management by using a new software, introduces the application of optimization toolbox in simulation of modern management and gains much better effects. Optimization programs needn't be prepared and design efficiency is greatly improved. At same time, more reliable optimization algorithms are used in optimization toolbox so that the design accuracy is also greatly improved.