How to make buildings acclimate to the climate has been the challenge of architecture for energy efficiency. This article suggests a Bio-inspired Kinetic Envelope (BKE) system responding to solar radiation and local climate conditions. In order to explore the envelope system, this research reviews important literatures related to biomimetic design in architecture and kinetic/interactive building envelope applications. Then, this study proposes and interprets the BKE system and in turn places it into a design case as the implementation example. A couple method of Parametric Design of Building Information Modeling (BIMPD) and computational simulation is used in this research. In the end, this article develops a research conceptual process for the study. Based on initial research, bio-inspired building envelopes may offer significant energy efficiency for indoor thermal comforts, but the resulting energy performance of BKE system depends on the locations' climatic conditions.