Comprehensive reform of college physical education curriculum is expounded from the reforms of sports mechanism, curriculum goals, physical curriculum structure, physical education curriculum instruction and physical education curriculum evaluation system. The whole system shall breakthrough the traditional physical education concepts insist on the guiding ideology of 'Health First', embody the value of health, utility, sustainable development, evaluation concept of perspectives of incentive and development. In addition, countermeasure for the comprehensive reform of college physical education curriculum is introduced in detail.