The problem of angular shaft misalignment in motors-load systems coupled through flexible couplings is analyzed in this work. A model for the analysis and diagnosis of angular misalignment in induction motors is presented. It allows studying the angular shaft misalignment effects over the motor torque, instantaneous power and currents through dynamic simulation. Additional effects introduced by the mixed eccentricity produced by the shaft misalignment are also analyzed through experiments. The results show that angular misalignment can be detected from electrical motor variables, but its correct diagnosis is difficult. The study is completed by vibration and thermography analysis.