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The high velocity gas flow of missile vertical launching process in the concentric canister launcher (CCL) was studied by computational fluid dynamics method. The motion on the domain boundaries of the fluid flow due to missile launching was modeled by dynamic layering mesh and sliding meshes technology. The Spalart-Allmaras one-equation model was chosen to modeling the turbulence. The heat transfer between high temperature gas and missile was simulated by fluid-solid coupling computing and the temperature on missile surface was given. It was shown that the dynamic mesh methods used in this paper was valid for missile launching process. The high temperature gas ejecting from outer canister was sucked into inner canister during missile launching. The missile was heated up by high temperature flow in inner canister; the increment of temperature on the missile surface was about 200K. The over-ablation of missile could be avoided.