Sequence families with zero or low correlation zone can be used in the quasi-synchronous code-division multiple-access (QS-CDMA) communication systems. Interleaving techniques are very useful for sequence design. In this paper, we present a general construction of sequence families with zero or low correlation zone using interleaving techniques and complex Hadamard matrices. The component sequences are perfect or ideal two-level. In two cases, we construct the shift sequences: 1) P|L; 2) P is even, and L ?? P/2 (mod P). The conditions are derived under which the new construction is optimal. Some examples are also given to specify the new construction.