Region management information system is a three-dimensional structure which contains management dimension, system architecture dimension and data dimension. In this article, the author introduced the grid management model into region management information system as management dimension, and designed the region management system using SOA as system architecture dimension, and used grid-based region's spatial data and other business data as data dimension. This paper took the workflow engine service platform as the system's core, combined with the natural semantic analytic location serve and mobile client system based on SOA architecture, formed a complete grid-based region management system designed based on SOA architecture.