With the diversification of in the high and span construction form, the structure vibration problem has become more prominent under load such as earthquake and wind power. Simple design that through increased cross-section or enhance the components stiffness method shows it is unreasonable more and more, at the same time, the application of intelligent materials and smart structure make an opening in the vibration control technology, and it has become one of the most cutting-edge work in the structure field. Based on the semi-active control mechanical model, derive and analysis the location optimization of MR dampers, and introduced implement method for the optimize layout. Based on a seven-story frame structure for the simulation, which can see the intelligent control results of the structure are obvious, and MR dampers control effects is non-importation of seismic waves varies, and closely related to the structure of its own parameters, through the optimization of the location of the layout, which can be achieve good control effect arranged little damper.