In May 2008, SFDA released the implementation scheme of drug electronic supervision work, bringing forward clear requirements for the informatization supervision work of drug safety. The condition of standardizing the enterprise operation process through implementing GSP management software aiming at the electronic supervision of the drug retail enterprises has been mature. This paper carries out deep research, practice exploration and detailed explanation aiming at the three key problems of the electronic supervision of drug retail enterprises: compulsory enforcement of GSP flow, safe storage of GSP information, stable upload of GSP data. The paper also makes expectation combining the development trend of drug supervision in China and aiming at the future development of the electronic supervision work of the drug retail enterprises.