As the rapid development of information technology, the learning style has been changing tremendously. E-learning as the result of this technology development, it has been changing our work, life and learning. The essential part of e-learning is Internet and other digital device, Internet has played an important role in global education and training. As a important work, life and learning style, e-learning has its special feature and function. However, during the e-learning process, physiological and psychological fatigue caused by human computer interaction and learning process becomes an important problems, it is also one of the most obstacles to efficient learning working. So, how to overcome this problem is the focus of e-learning. In present paper, we discuss fatigue feedback technique used in e-learning and its application in e-learning process.