To enhance management and cooperation of nodes in wireless sensor networks (simply WSNs), a local indicator of spatial autocorrelation (namely LISA) based sub-area algorithm, LISABSAA, is presented. Firstly, LISABSAA divides WSNs into spatial virtual grids, which are basic management units. According to LISAs of different spatial virtual grids, LISABSAA then divides WSNs into different areas by combining neighboring spatial objects. Experimental results show that LISABSAA can efficiently sub-area WSNs by LISABSAA.