In large-scale ozone generators for industrial or public utilities applications, low-power consumption, robustness of operation, and minimum maintenance requirements are of the highest importance. In order to meet these operational parameters, this paper explores the possibility to use inhomogeneous feed gas processing in a new generation of large-scale ozone generators. We utilize a finite-element model to simulate a discontinuous power induction along the length of the ozone generator tube. The simulation yields the local power density, the local gas temperature gradient, and a relative dielectric barrier discharge (DBD) filamentation packing density. This information, in conjunction with experimental data, provides a sufficiently broad basis of information to infer a correlation between the electrode arrangement and the ozone generation efficiency and overall ozonizer performance. Several ozonizer configurations were designed, simulated, manufactured, tested, and their performance was assessed. This led to a new design for large-scale ozone generators with the possibility of increasing ozone formation efficiency through the tailoring of the DBD microdischarges or microplasmas. The new arrangement tolerates a higher power induction at the inlet of the ozonizer, which has several advantages over constant power induction arrangements. The degree of DBD filamentation emerges as the decisive factor that enables the tailoring of the plasma. Evidence of an increased O3 generation efficiency and significantly reduced electrical power consumption are shown on an industrial-scale ozonizer with more than 100 m2 of active DBD microplasma area.