This paper presents a novel cavity backed slot (CBS) antenna for subsurface sensing applications. The CBS antenna is designed to be "matched" in the two-half-space configuration (one half space air; and the other ground) over a relatively wide frequency band. As a result, when attached onto ground surface, it is able to efficiently couple microwave power into and out of the ground. In this study, CBS antennas with operating frequency range [8.5 GHz, 13.6 GHz] are designed to detect objects buried in sand. Data acquisition is carried out using a sandpit with size (125 cm times 100 cm times 80 cm) as the test bed. One transmitting CBS antenna is fixed at the center of the sandpit and one receiving antenna is physically moved along a rectangular grid (i.e., multi-static measurement). An inverse synthetic aperture radar (ISAR) algorithm is adopted for inverse processing. A 4-inch-diameter metallic sphere is used as calibration target; and three targets are tested, including a 3-inch-diameter metallic sphere, a T-shaped copper target, and a landmine simulant. Imaging results are presented and compared with those obtained using horn antennas (which are not "matched" to the air-ground interface). Better signal-to-clutter ratios are demonstrated by the proposed CBS antennas.