The train control center which plays a central role of message communication is a pivotal sub-system of the china train control system. On the basis of developing and debugging the engineering prototype of the train control center, an index system for evaluating the safety of the train control center was set up. Based on the analytic hierarchy process, a safety evaluation method for the train control center was proposed. Using the technology of verification, validation and accreditation, comprehensive analysis to the safety evaluation index of the train control center was carried on. At last, the safety evaluation index of the whole train control center was obtained, which is useful to the nationalized train control center.