Combined with the technology of PDA and WLAN, and in view of limitations of wired networking in current hospital nursing workstations, this paper designs and implements a mobile nursing information system based on B/S taking PDA as its running platform. This system is a natural extension of the existing HIS, which takes patients as its center. And its application can optimize the work flow of clinical nursing, raise work efficiency of nursing personnel, promote service quality of medical treatment, improve hospital nursing management, and reduce medical accidents.