Nowadays the implementation of highly integrated UHF RFID reader transceiver RF front-ends with excellent performance is demanding and is still challenging. This paper presents a number of design considerations from the system point of view, including the choice of receiver/transmitter front-end architecture, isolation between transmitter and receiver, power efficiency of the transmitter. Some critical system performance issues like sensitivity, noise figure, dynamic range and AGC operation, LO phase noise, et al. are also presented.