Water resource environment conflict becomes the important factors of endangering the peace and stability of regions and restricting the sustainable development of theirs. Many cross area issues of water resources environment are the game outcomes among regional governments who compete for resources and environment for their own regional benefit. It has become one of the important duties of water resources management to alleviate the water resources conflict of river basin and to promote the negotiation and cooperation between regions. From the macro-perspective, combined with the management of water resources environment in China, a model of multi-region game is constructed in this paper. The interactive compromise procedure for multi-region game is given to solve the multi-region game, in which the theory of negotiation for multi-objective game and the method of interactive multi-objective decision making are integrated and the public decision-making is considered. This procedure provides an efficient method of preventing from and alleviating water resources conflict in a river basin and a feasible realized platform for public participation and group decision-making in water resources management.