This paper studies optimization problem of materials procurement, storage in construction projects. With the thought of operations research, it designs objective function and constrained conditions for a materials procurement and storage optimization model. To testify the model, a specific project is studied. According to historical market data, it simulates the target cost while the factors such as market price changes to find a best cost plan by MATLAB. The method provided can be used to analyze the rule of materials procurement and storage cost and make a correct decision, or to solve the problem of analyzing and forecasting procurement and storage cost of the main material in construction projects under the relevant factors (single or multiple) uncertain.