The problem of decoupling to time, space and flow in distributed object-oriented middleware asynchronous communication is studied in this paper. We adopt publish/subscribe (P/S) scheme in CORBA distributed circumstance based on analysis to the problem in current distributed object-oriented middleware communication mechanism and build CORBA communication system based on P/S model. At the same time, in order to solve the problem of decoupling to the three aspects in distributed object-orient middleware asynchronous communication we introduce mobile agent technique in P/S middleware broker system to establish an asynchronous communication algorithm based on mixture model of agent and P/S.